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Using
dielectrophoresis (DEP) and micro electrode
technology to offer unrivalled speed, accuracy and
sensitivity in detecting bacteria from platelet
samples. |
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Products |
New
Bac-Detect™... |
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Bac-Detect™ is a rapid
screening technology for bacterial contamination of
platelets and can be used at any time from
collection, during storage and at a point of issue
or transfusion. |
Reasons to
consider point of issue testing for bacterial
contamination of platelets:
• Up to 50% of
bacterially contaminated platelets may escape
detection by culture at 24 hours1.
Bac-Detect™ does not require culture for
bacterial detection.
• The risk of failure
to detect slow growing contaminant bacteria is
reduced2.
Bac-Detect™ can measure bacterial
contamination at the end of the storage time.
• Point of issue
requires a lower threshold of sensitivity thereby
improving reliability. Clinically relevant bacterial
load for all serious reactions at point of issue is
104CFU/ml3,4.
Bac-Detect™ can detect a single bacterium
from a 1ml sample. Detection rates are subject to
sampling procedures.
• Pathogen
inactivation by photochemical treatment reduces
platelet quality during storage5.
Testing with
Bac-Detect™ does not
affect the viability of platelets or introduce toxic
compounds into the product.
• Point of issue
testing may permit the safe issue of 7 day storage
platelets. Currently, platelets should not be stored
for longer than 5 days if they are tested for
bacterial contamination by culture methods at 24
hours6.
Testing at point of
issue with Bac-Detect™
removes the risk of increased bacterial load
during storage. |
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References |
1. Elder AF et al (2007) Bacterial screening of
apheresis platelets and the residual risk of septic
transfusion reactions: the American Red Cross
Experience (2004-2006). Transfusion, 47,
1134.
2. Prowse C (2007) Editorial ; Zero tolerance.
Transfusion, 47, 1106.
3. Palavecino EL et al (2006) Review. Detecting
bacterial contamination in platelet products.
Clinical Laboratory, 52, 443.
4. Jacobs MR et al (2008) Relationship between
bacterial load, species virulence, and transfusion
reaction with transfusion of bacterially
contaminated platelets. Clinical Infectious
Diseases, 46, 1214.
5. Apelseth TO et al (2007) In vitro evaluation of
metabolic changes and residual platelet
responsiveness in photochemical treated and
gamma-irradiated single-donor platelet concentrates
during long-term storage. Transfusion, 47,
653.
6. www.passportstudy.com |
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